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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are often focused on practical aspects of the study design, including the recruitment process and consent, adherence, and the use of standard equipment.Free spins
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed different investigators and had participants from different geographical regions. This kind of heterogeneity, that is crucial for a pragmatic trial to be reliable and lessen the chance of bias, is also necessary. However, too much heterogeneity could cause issues with the design of the trial.
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The aim of pragmatic trials is to replicate real-life scenarios and to achieve maximum validity externally. They are usually commissioned by practitioners and 프라그마틱 정품 policy makers to aid in their decision-making. They can also be used to assess the causal relationship between an intervention and its results. However, they should not be used in lieu for explanation trials.
The pragmatism idea is controversial and there are concerns regarding whether pragmatic trials could replace explanatory tests or if they should be a complement to them. Schwartz and Lellouch1 made the distinction between explanation studies, which support the validity of a physiological or clinical hypothesis, and pragmatic trials that aid in policy and practice decision-making. They also proposed a framework for pragmatic trials, which they called PRECIS.2 This tool sought to define the characteristics of a pragmatic trial that include recruitment, design and delivery of the intervention, as well as the follow-up.
There is an encouraging trend in the number of pragmatic trials published. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs) resulted in 34 articles, as shown in red in Figure 2. This is an indication that the health science community is becoming more acquaint to the subject of pragmatism. It is important to remember, however, that the majority were conducted in primary-care settings.